Human cancer cells were transplanted into deficiency spontaneous mutation immune (SCID) mice. Twenty mice were divided into four groups as follow:

Group A: +“Tzofen vector” + prodrug

Group B: +“Tzofen vector” – prodrug

Group C: –“Tzofen vector” + prodrug

Group D: –“Tzofen vector” – prodrug

The growth rate of the tumors was monitored by measuring the luciferase light intensity. Tumor growth measurements were prepared to be taken once a week for 35 days following transplantation. Images of light emission from the mice were taken on 7, 14, 28 and 35 days post-transplantation. As can be seen, tumor growth was significantly reduced following treatment with TZ-101 and prodrug relative to all other control groups.